abstract：INTRODUCTION:We report the SVR12 final analysis of a phase 3 study of telaprevir in combination with peginterferon (P)/ribavirin (R) in HCV-genotype 1, treatment-naïve and -experienced patients with HCV/HIV co-infection (INSIGHT). MATERIALS AND METHODS:Patients receiving stable, suppressive HIV antiretroviral (ARV) th...

journal_title：Journal of the International AIDS Society

authors： Montes M,Nelson M,Girard PM,Sasadeusz J,Horban A,Grinsztejn B,Zakharova N,Rivero A,Lathouwers E,Janssen K,Ouwerkerk-Mahadevan S,Witek J

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Several factors such as duration of infection, age, male gender, consumption of alcohol, HIV infection and low CD4 count have been associated with fibrosis progression rate. However, it is relatively scarce, the knowledge about the liver fibrosis progression rate in HIV-infected patients with undetectable ...

journal_title：Journal of the International AIDS Society

authors： Perez-Martinez L,Sanjoaquin I,Rivero M,Gil-Pérez D,Letona S,Olaiz CI,Arazo P,Blanco JR

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Women living with HIV (WLWH) are reportedly at increased risk of invasive cervical cancer (ICC). WLWH in Denmark attend the National ICC screening program less often than women in the general population. We aimed to estimate the incidence of cervical dysplasia and ICC in WLWH in Denmark. METHODS:We studie...

journal_title：Journal of the International AIDS Society

authors： Thorsteinsson K,Ladelund S,Jensen-Fangel S,Katzenstein TL,Johansen IS,Pedersen G,Junge J,Helleberg M,Storgaard M,Obel N,Lebech AM

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Due to their low CNS penetrance, there are concerns about the capacity of non-conventional PI-based ART (monotherapy and dual therapies) to preserve neurocognitive performance (NP). METHODS:We evaluated the NP change of aviremic participants of the SALT clinical trial (1) switching therapy to dual therapy...

journal_title：Journal of the International AIDS Society

authors： Valero IP,Pasquau J,Rubio R,Ribero A,Santos J,Sanz J,Mariño A,Crespo M,Hernandez J,Iribarren JA,Gutierrez F,Terron A,Esteban H,Pérez-Molina JA

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:The Robert Koch Institute (RKI) aimed to assess a molecular surveillance strategy based on filter-dried serum spots (DSS) of all newly diagnosed HIV infections in Germany. In 2013, diagnostic laboratories sent DSS to the RKI representing 55% of the newly diagnosed HIV infections reported to the RKI (protec...

journal_title：Journal of the International AIDS Society

authors： Andrea H,Alexandra H,Claudia SH,Ruth Z,Osamah H,Norbert B,Claudia K

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:The clinical value of monitoring CD4 counts in immune reconstituted, virologically suppressed HIV-infected patients is limited. We investigated if absolute lymphocyte counts (ALC) from an automated blood counting machine could accurately estimate CD4 counts. MATERIALS AND METHODS:CD4 counts, ALC and HIV v...

journal_title：Journal of the International AIDS Society

authors： Young B,Lye D,Ng OT,Leo YS

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:It is estimated that over half of newly diagnosed HIV infections in Europe present late. An HIV positive individual presenting late to care represents a missed opportunity to benefit from treatment, increasing the risk of morbidity and mortality at an individual level, and onward disease transmission at po...

journal_title：Journal of the International AIDS Society

authors： Shivaji T,Diniz A,Cortes-Martins H

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:In South Africa where replacement feeding may not be affordable, feasible or sustainable, HIV-infected women are recommended to exclusively breastfeed their infants during the first six months of life. The question arises whether HIV disease progression and its metabolic impact on the mother will affect th...

journal_title：Journal of the International AIDS Society

authors： van den Heever W,de Wet G,Hattingh M

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Cardiovascular disease (CVD) is the leading cause of death in England and Wales. As people living with HIV (PLWH) age, proactive management of CVD risk factors is crucial. The long-awaited draft guidelines for CVD from the National Institute of Clinical Excellence (NICE) propose lipid modification (with st...

journal_title：Journal of the International AIDS Society

authors： Ahmed N,Bradley S,Pearson P,Edwards S,Waters L

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Disruption in bone homeostasis with increased osteoclastic resorption may lead to osteoporosis. HIV tat has been found to increase differentiation of precursor cells into osteoclast (OC) (1). Presence of soluble HIV proteins in virally suppressed HIV patients on ART may drive a bone resorption phenotype. W...

journal_title：Journal of the International AIDS Society

authors： Chew N,Tan E,Li L,Lim R

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Consistent use of PrEP reduces HIV transmission from sexual practices amongst men who have sex with men (MSM) up to 92% [1]. Lisbon MSM cohort study estimates point that 59.3% of their participants at entrance (1593 HIV negative MSM enrolled between April 2011 and May 2013) were eligible for PrEP [2], acco...

journal_title：Journal of the International AIDS Society

authors： Rocha LM,Campos MJ,Brito J,Fuertes R,Rojas J,Pinto N,Mendão L,Esteves J

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:HIV-1 viral escape in the cerebrospinal fluid (CSF) despite viral suppression in plasma is rare [1,2]. We describe the case of a 50-year-old HIV-1 infected patient who was diagnosed with HIV-1 in 1995. Antiretroviral therapy (ART) was started in 1998 with a CD4 T cell count of 71 cells/ìL and HIV-viremia o...

journal_title：Journal of the International AIDS Society

authors： Béguelin C,Vázquez M,Bertschi M,Yerly S,de Jong D,Rauch A,Cusini A

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Dolutegravir is a second generation integrase inhibitor with a proposed high genetic barrier to resistance. However, in clinical trials, decreased virological response was seen in a subset of patients with prior exposure to raltegravir and multiple integrase resistance mutations. METHODS:We describe two c...

journal_title：Journal of the International AIDS Society

authors： Hofstra LM,Nijhuis M,Mudrikova T,Fun A,Schipper P,Schneider M,Wensing A

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Clinicians often do not have the time and possibilities to read all scientific evidence necessary to maintain high quality patient care. They rely on guidelines made by experts to help them in their daily work. METHODS:We compared the 2012 recommendations and the arguments of the IAS-USA Panel with the da...

journal_title：Journal of the International AIDS Society

authors： Piso RJ

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:The long-term effects of an intensified induction regimen are unknown. In this pilot, randomized, prospective study we evaluate the effect of a short-term four-drugs induction regimen in patients with high baseline viral load. METHODS:Naive patients with HIV-RNA>100.000 copies/ml receiving TDF+FTC+EFV+RAL...

journal_title：Journal of the International AIDS Society

authors： Maggiolo F,Masini G,Astuti N,Di Filippo E,Benatti S,Valenti D,Callegaro AP,Rizzi M

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:This was a descriptive non-interventional study in HIV-1-infected patients treated with DRV/r conducted in the clinical setting, with a single-arm prospective design. The primary objective was to collect data on utilization of darunavir/ritonavir (DRV/r) under the conditions described in the marketing auth...

journal_title：Journal of the International AIDS Society

authors： Antinori A,Galli M,Gianotti N,Mussini C,Quirino T,Sterrantino K,Mancusi D,Termini R

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Rilpivirine (RPV) is a new once-daily, non-nucleoside, reverse transcriptase inhibitor (NNRTI). In treatment-naïve patients, RPV has shown non-inferior antiviral activity to efavirenz but data in treatment-experienced patients are more limited. We assessed the efficacy and safety of RPV in treatment-experi...

journal_title：Journal of the International AIDS Society

authors： Gazaignes S,Resche-Rigon M,Yang C,Gatey C,Munier AL,Desseaux K,Rozenbaum W,Molina JM

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:The 48-week interim analysis of the MODAT study showed that confirmed virologic failure (CVF) was more frequent in patients simplifying to ATV/r monotherapy compared to maintaining ATV/r-based triple therapy. The DSMB recommended stopping study enrollment but continuing follow-up of enrolled patients. We p...

journal_title：Journal of the International AIDS Society

authors： Spagnuolo V,Galli L,Bigoloni A,Nozza S,Monforte Ad,Antinori A,Di Biagio A,Rusconi S,Guaraldi G,Di Giambenedetto S,Lazzarin A,Castagna A

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Low bone mineral density (BMD) and osteoporosis are prevalent in HIV-infected patients and were associated with HIV infection and tenofovir-containing ART. MATERIALS AND METHODS:The GUSTA study (GUided Simplification with Tropism Assay) is a two-arm, prospective, multicenter, 1:1 randomized controlled tri...

journal_title：Journal of the International AIDS Society

authors： Bianco C,Rossetti B,Gagliardini R,Lamonica S,Fanti L,Lombardi F,Cauda R,Di Giambenedetto S,De Luca A

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:Recent data indicates that low vitamin D (25(OH)D) levels can lead to a worst prognosis in HIV-infected individuals, even in those on successful antiretroviral therapy (ART) [1]. Portugal is the European country that has the largest average sun exposure time but prevalence of hypovitaminosis D is mostly un...

journal_title：Journal of the International AIDS Society

authors： Boura M,Sutre AF,Badura R,Zagalo A,Afonso C,Caldeira L,Valadas E

更新日期：2014-11-02 00:00:00

abstract：INTRODUCTION:We compared the effectiveness of tenofovir/emtricitabine (TDF/FTC) combined with either lopinavir/r (LPV/r) or another recommended third drug in the 2010 French guidelines in antiretroviral-naïve patients starting combination antiretroviral therapy in 2004-2008 in the French Hospital Database on HIV. METH...

journal_title：Journal of the International AIDS Society

authors： Potard V,Rey D,Poizot-Martin I,Mokhtari S,Pradier C,Rozenbaum W,Brun-Vezinet F,Costagliola D,FHDH ANRS CO4 (French Hospital Database on HIV, Agence Nationale de Recherches sur le Sida, cohort 4).

更新日期：2014-09-25 00:00:00

abstract：INTRODUCTION:Antiretroviral (ARV)-based pre-exposure prophylaxis (PrEP) is a promising new HIV prevention strategy. However, variable levels of adherence have yielded mixed results across several PrEP trials and populations. It is not clear how taking ARV - traditionally used for HIV treatment - is perceived and how th...

journal_title：Journal of the International AIDS Society

authors： van der Straten A,Stadler J,Luecke E,Laborde N,Hartmann M,Montgomery ET,VOICE-C Study Team.

更新日期：2014-09-08 00:00:00

abstract：INTRODUCTION:Two new microbicide products based on topical (vaginal) application of antiretroviral drugs - 1% tenofovir gel and the dapivirine ring - are currently in late-stage clinical testing, and results on their safety and effectiveness are expected to become available in early 2015. WHO guidelines on the use of t...

journal_title：Journal of the International AIDS Society

authors： Lusti-Narasimhan M,Khosla R,Baggaley R,Temmerman M,McGrory E,Farley T

更新日期：2014-09-08 00:00:00

abstract：INTRODUCTION:Antiretroviral therapy (ART) substantially improves the health of people living with HIV and contributes to preventing new infections. While HIV incidence is decreasing in most regions, the epidemic in eastern Europe continues to rise, as new infections currently outnumber the rate of ART initiation. In th...

journal_title：Journal of the International AIDS Society

authors： Mallitt KA,Grigoryan SR,Papoyan AS,Wand HC,Wilson DP

更新日期：2014-08-04 00:00:00

abstract：INTRODUCTION:Scientific research has demonstrated the clinical benefits of earlier initiation of antiretroviral treatment (ART), and that ART can markedly reduce HIV transmission to sexual partners. Ensuring universal access to ART for those who need it has long been a core principle of the HIV response, and extending ...

journal_title：Journal of the International AIDS Society

authors： Grubb IR,Beckham SW,Kazatchkine M,Thomas RM,Albers ER,Cabral M,Lange J,Vella S,Kurian M,Beyrer C,IAS Treatment for Key Affected Populations Working Group.

更新日期：2014-07-18 00:00:00

abstract：INTRODUCTION:Rilpivirine (RPV) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) that was recently approved for the treatment of antiretroviral-naïve individuals with HIV-1 viral load of <100,000 copies/ml. As transmission of the drug resistance mutations to this NNRTI may affect treatment o...

journal_title：Journal of the International AIDS Society

authors： Parczewski M,Urbańska A,Maciejewska K,Witak-Jȩdra M,Leszczyszyn-Pynka M

更新日期：2014-04-17 00:00:00

abstract：INTRODUCTION:HIV-1-associated CD4+ T-cell depletion is a consequence of uninfected cell death. Nef is one of the viral factors that trigger apoptosis on bystander cells, though the plasma Nef levels do not correlate with Th lymphocytes counts. The aim of our study was to evaluate whether anti-Nef antibodies were involv...

journal_title：Journal of the International AIDS Society

authors： Corró G,Crudeli CM,Rocco CA,Marino SA,Sen L

更新日期：2014-02-14 00:00:00

abstract：INTRODUCTION:There are limited data characterizing the burden of HIV among men who have sex with men (MSM) in Malawi. Epidemiologic research and access to HIV prevention, treatment and care services have been traditionally limited in Malawi by criminalization and stigmatization of same-sex practices. To inform the deve...

journal_title：Journal of the International AIDS Society

authors： Wirtz AL,Jumbe V,Trapence G,Kamba D,Umar E,Ketende S,Berry M,Strömdahl S,Beyrer C,Baral SD

更新日期：2013-12-02 00:00:00

abstract：INTRODUCTION:Stigma associated with HIV has been documented as a barrier for accessing quality health-related services. When the stigma manifests in the health care setting, people living with HIV receive substandard services or even be denied care altogether. Although the consequences of HIV stigma have been documente...

journal_title：Journal of the International AIDS Society

authors： Varas-Díaz N,Neilands TB,Cintrón-Bou F,Marzán-Rodríguez M,Santos-Figueroa A,Santiago-Negrón S,Marques D,Rodríguez-Madera S

更新日期：2013-11-13 00:00:00

abstract：:Improved knowledge, better programmes and policies, effective treatment and other scientific developments have reduced levels of new HIV infections globally. Evidence shows that programmes that prevent HIV among sex workers and their clients are most successful when all aspects of vulnerability are addressed and when ...

journal_title：Journal of the International AIDS Society

authors： Overs C,Loff B

更新日期：2013-08-29 00:00:00

abstract：INTRODUCTION:Anaemia is prevalent among children born to HIV-positive women, and it is associated with adverse effects on cognitive and motor development, growth, and increased risks of morbidity and mortality. OBJECTIVE:To examine the effect of daily multivitamin supplementation on haematologic status and mother-to-c...

journal_title：Journal of the International AIDS Society

authors： Liu E,Duggan C,Manji KP,Kupka R,Aboud S,Bosch RJ,Kisenge RR,Okuma J,Fawzi WW

更新日期：2013-08-13 00:00:00

abstract：INTRODUCTION:A severe healthcare worker shortage in sub-Saharan Africa is inhibiting the expansion of HIV treatment. Task shifting, the transfer of antiretroviral therapy (ART) management and initiation from doctors to nurses and other non-physician clinicians, has been proposed to address this problem. However, many h...

journal_title：Journal of the International AIDS Society

authors： Emdin CA,Chong NJ,Millson PE

更新日期：2013-07-03 00:00:00

abstract：INTRODUCTION:Human immunodeficiency virus (HIV) infection is a primary cause of acquired heart disease, particularly of accelerated atherosclerosis, symptomatic heart failure, and pulmonary arterial hypertension. Cardiac complications often occur in late-stage HIV infections as prolonged viral infection is becoming mor...

journal_title：Journal of the International AIDS Society

authors： Lipshultz SE,Miller TL,Wilkinson JD,Scott GB,Somarriba G,Cochran TR,Fisher SD

更新日期：2013-06-18 00:00:00

abstract：INTRODUCTION:Since 2003, US government funding to address the HIV and AIDS pandemic has been subject to an anti-prostitution clause. Simultaneously, the efficacy of some HIV prevention efforts for sex work in areas receiving US government funding has diminished. This article seeks to explain why. METHODS:This analysis...

journal_title：Journal of the International AIDS Society

authors： Ditmore MH,Allman D

更新日期：2013-03-28 00:00:00

abstract：INTRODUCTION:Inadequate knowledge, negative attitudes and risky practices are major hindrances to preventing the spread of HIV. This study aimed to assess HIV-related knowledge, attitudes and practices (KAPs) of high school students in Lao People's Democratic Republic (PDR). METHODS:A cross-sectional study on unmarrie...

journal_title：Journal of the International AIDS Society

authors： Thanavanh B,Harun-Or-Rashid M,Kasuya H,Sakamoto J

更新日期：2013-03-11 00:00:00

abstract：INTRODUCTION:Virtually no African country provides HIV prevention services in sex work settings with an adequate scale and intensity. Uncertainty remains about the optimal set of interventions and mode of delivery. METHODS:We systematically reviewed studies reporting interventions for reducing HIV transmission among f...

journal_title：Journal of the International AIDS Society

authors： Chersich MF,Luchters S,Ntaganira I,Gerbase A,Lo YR,Scorgie F,Steen R

更新日期：2013-03-04 00:00:00

abstract：INTRODUCTION:Recent debates on how to achieve an optimal HIV response are dominated by intervention strategies that fail to recognize children's role in the community response to HIV. Whilst formal responses are key to the HIV response, they must recognize and build on indigenous community resources. This study examine...

journal_title：Journal of the International AIDS Society

authors： Skovdal M,Magutshwa-Zitha S,Campbell C,Nyamukapa C,Gregson S

更新日期：2013-02-04 00:00:00

abstract：INTRODUCTION:Linkage from HIV testing and counselling (HTC) to initiation of antiretroviral therapy (ART) is suboptimal in many national programmes in sub-Saharan Africa, leading to delayed initiation of ART and increased risk of death. Reasons for failure of linkage are poorly understood. METHODS:Semi-structured qual...

journal_title：Journal of the International AIDS Society

authors： MacPherson P,MacPherson EE,Mwale D,Bertel Squire S,Makombe SD,Corbett EL,Lalloo DG,Desmond N

更新日期：2012-12-31 00:00:00

abstract：INTRODUCTION:Despite recent advances in the management of HIV infection and increased access to treatment, prevention, care and support, the HIV/AIDS epidemic continues to be a major global health problem, with sub-Saharan Africa suffering by far the greatest humanitarian, demographic and socio-economic burden of the e...

journal_title：Journal of the International AIDS Society

authors： Divaris K,Newman J,Hemingway-Foday J,Akam W,Balimba A,Dusengamungu C,Kalenga L,Mbaya M,Molu BM,Mugisha V,Mukumbi H,Mushingantahe J,Nash D,Niyongabo T,Atibu J,Azinyue I,Kiumbu M,Woelk G

更新日期：2012-11-21 00:00:00

abstract：BACKGROUND:The aim of our study was to assess the extent of late presentation for HIV care in Northern Greece during the period 2000 to 2010 and to explore correlations aiming to provide guidance for future interventions. METHODS:HIV-positive patients with no prior history of HIV care at presentation and with a CD4 T ...

journal_title：Journal of the International AIDS Society

authors： Metallidis S,Pilalas D,Skoura L,Haidich AB,Tsachouridou O,Papaioannou M,Chrysanthidis T,Bakaimi I,Antoniadou ZA,Margariti A,Malisiovas N,Nikolaidis P

更新日期：2012-10-11 00:00:00